Advancing oligonucleotide therapeutics: conjugation strategies for extrahepatic delivery

“A successful conjugate must effectively deliver oligonucleotides while maintaining safety, stability, and manufacturability.”

On August 20, 2025, Lauren Coyle, Launch Commissioning Editor, Bioconjugation Insights, spoke to Sritama Bose, Associate Director of Chemistry, Orfonyx Bio, about oligonucleotide bioconjugation strategies, delivery challenges, and emerging approaches for tissue-specific targeting. This viewpoint is based on that conversation.

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