Cell and Gene Therapy Insights Volume 11 Issue 1

CELL AND GENE THERAPY INSIGHTS

Volume 11 Issue 1

Cell and Gene Therapy Insights Volume 11 Issue 1

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Featuring

Issue Spotlight: Expanding cellular immunotherapy
Vectors focus: Manufacturing Scale-up 2025
Other articles
Webinars

Expanding cellular immunotherapy

David Morrow

Guest Editor:

David Morrow, Scientific Programme Manager, Translational Medicine & Drug Development at EATRIS

Foreword

Breaking barriers in cell and gene therapy: advancing ATMPs through innovation and collaboration

Breaking barriers in cell and gene therapy: advancing ATMPs through innovation and collaboration

A Ussi, A Andreu, F Bietrix et al.

28 February 2025

Innovator Insight

Worth the switch? Enhancing process performance for cell therapy manufacturing with an animal component-free raw material strategy

Worth the switch? Enhancing process performance for cell therapy manufacturing with an animal component-free raw material strategy

Phil Morton, Shanya Jiang

Commentary

CAR-T cells in B-cell mediated autoimmune diseases: do all roads lead to Rome?

CAR-T cells in B-cell mediated autoimmune diseases: do all roads lead to Rome?

Dimitrios Mougiakakos

13 February 2025

Viewpoint

Efficient non-viral engineering of immune cells for cell therapy using circular single-stranded DNA

Efficient non-viral engineering of immune cells for cell therapy using circular single-stranded DNA

13 January 2025

Interview

Solid tumor treatment: how can we achieve therapy efficacy and persistence in the next frontier of cell therapies?

Solid tumor treatment: how can we achieve therapy efficacy and persistence in the next frontier of cell therapies?

Sebastian Kobold

23 January 2025

Manufacturing Scale-up 2025

Interview

Addressing challenges in AAV manufacturing scale-up for cost-effective gene therapies

Addressing challenges in AAV manufacturing scale-up for cost-effective gene therapies

Andrew D Tustian

articles

Innovator Insight

Enabling allogeneic cell therapy development: scaling up generation of PSC-derived NK cells

Enabling allogeneic cell therapy development: scaling up generation of PSC-derived NK cells

Mark Kennedy, Marcus Bunn

Maximizing CAR-T cell yields: scalable solutions with perfusion and stirred-tank bioreactors

Maximizing CAR-T cell yields: scalable solutions with perfusion and stirred-tank bioreactors

J Hengst, Q Rafiq, R Ladi et al.

27 February 2025

Maximizing cell therapy process flexibility and efficiency with next-generation technologies

Maximizing cell therapy process flexibility and efficiency with next-generation technologies

19 February 2025

Speeding to success: accelerating cell therapy development and manufacturing workflows

Speeding to success: accelerating cell therapy development and manufacturing workflows

17 February 2025

Toward clinical-scale nonviral gene-edited CAR-NK cells for cell therapy

Toward clinical-scale nonviral gene-edited CAR-NK cells for cell therapy

Namritha Ravinder, Krishanu Saha

13 February 2025

Make more lentivirus and make it right the first time

Make more lentivirus and make it right the first time

Katherine Schewe

10 February 2025

Enhancing CAR-T therapy development: harnessing cell selection flexibility

Enhancing CAR-T therapy development: harnessing cell selection flexibility

Tamara Laskowski, Nuala Trainor

6 February 2025

Optimizing for the future: streamlining the production of T cell-based immunotherapies

Optimizing for the future: streamlining the production of T cell-based immunotherapies

Soong Poh Loong, Paula Lam

28 January 2025

Expert Roundtable

Why peer review matters: insights from the scientific community

Why peer review matters: insights from the scientific community

A Goyal, A Cockroft, P Theocharous et al.

28 February 2025

Webinar Digest

Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Brandon Goldberg

3 February 2025

Poster

INTERACTIVE EVENT SUMMARY: Harnessing flow cytometry for high-throughput screening in immunotherapy development

INTERACTIVE EVENT SUMMARY: Harnessing flow cytometry for high-throughput screening in immunotherapy development

20 January 2025

Interview

Regulatory innovations: why is the UK an attractive hub for CGT development?

Regulatory innovations: why is the UK an attractive hub for CGT development?

Rehma Chandaria

13 February 2025

Driving innovation in cell and gene therapy: the role of AI and robotics

Driving innovation in cell and gene therapy: the role of AI and robotics

Kenneth Harris, Mitchel Sivilotti, Anthony Rotunno

27 January 2025

Conference Insight

The Nordics are dancing on

The Nordics are dancing on

Helena Strigard

23 January 2025

Forecast

New frontiers for cell and gene therapy: addressing 2024 milestones and the outlook for 2025

New frontiers for cell and gene therapy: addressing 2024 milestones and the outlook for 2025

A Bersenev, F Salmon, J Dowd et al.

Case study: developing an ex vivo gene-modified hematopoietic stem cell treatment for a rare monogenic disease in a novel mouse model

Case study: developing an ex vivo gene-modified hematopoietic stem cell treatment for a rare monogenic disease in a novel mouse model

Rafael A. Badell-Grau

29 January 2025

Big pharma case study: alpha testing of a generic anti-AAV kit and comparison to in-house methods

Big pharma case study: alpha testing of a generic anti-AAV kit and comparison to in-house methods

Kira Hedström, Eva-Maria Thüring

30 January 2025

Advancing AAV manufacturing: strategic insights and cost-effective solutions for the future of gene therapies

Advancing AAV manufacturing: strategic insights and cost-effective solutions for the future of gene therapies

M DiBiasio-White, Y Cai, R Pach

6 February 2025

Producing engineered extracellular vesicles with a platform approach

Producing engineered extracellular vesicles with a platform approach

Sriram Sathy, Vijetha Bhat

13 February 2025

Closed and automated CAR-T production: a fast, simple workflow for high-dose, high-quality cells

Closed and automated CAR-T production: a fast, simple workflow for high-dose, high-quality cells

Wenyan Leong, Louise Tan

19 February 2025

Avoiding scale-up pitfalls: upstream process development strategies for AAV manufacturing

Avoiding scale-up pitfalls: upstream process development strategies for AAV manufacturing

Sandy Tseng, Hugh Murray

26 February 2025

Efficient AAV purification: resin reuse and scalable polish method

Efficient AAV purification: resin reuse and scalable polish method

Nicolas Laroudie, Duncan Dulac