A more perfect disease model – engineered iPSCs from innovation to discovery

Wednesday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST

Sponsor

A more perfect disease model – engineered iPSCs from innovation to discovery

Join leading researchers as they reveal how targeted iPSC engineering is transforming disease modeling and accelerating discovery. Our expert speakers will discuss how iPSCs are enabling highly specific control for more reproducible and patient relevant discovery.

Advanced gene tagging techniques
Discover how Oscar Perez (Temple University) uses a system for simultaneous insertion of fluorescent protein tags into multiple genes within iPSCs enabling the creation of cellular models that retain tagged proteins even after differentiation into disease-relevant cell types.

Using CRISPR-edited iPSCs to study neurodevelopmental disorders
Learn about how mapping genetic variants to altered protein interactions in CRISPR-edited iPSCs, offers new perspectives on the mechanisms behind autism spectrum disorder.

Optimized protocols for culture and single cell cloning
Hear from Chris Heger (Bio-Techne) on refining experimental workflows for culturing and cloning a wide range of cell types from immortalized lines to iPSCs using gentle, microfluidic single-cell isolation.

Join the webinar to:

Learn how to engineer iPSCs with precise, multi-gene fluorescent tagging to create robust, disease-relevant cellular models.
Gain insights into using CRISPR-edited iPSCs to map genetic variants and uncover disease mechanisms
Discover optimized workflows for culture and single-cell cloning across diverse cell types
Understand how gentle microfluidic sorting enhances single-cell isolation to streamline workflows and produce more relevant disease models

Oscar Perez

Associate Professor at Temple University School of Pharmacy

Dr. Oscar Perez-Leal is an Associate Professor at Temple University School of Pharmacy in Philadelphia, where he specializes in molecular biology, genome editing, and drug discovery. He received his Medical Degree from Universidad del Norte in Barranquilla, Colombia (2002) and completed postdoctoral training at Temple University School of Medicine. Dr. Perez-Leal developed the patented FAST-HDR system, a technology that enables CRISPR-mediated multiplex gene tagging with fluorescent proteins for real-time cellular analysis and drug screening. Currently, Dr. Perez-Leal is working to improve genome editing methods for creating disease models with induced pluripotent stem cells (iPSCs), developing cellular systems that retain multiple endogenous tagged proteins after differentiation and offer advantages over conventional laboratory cell lines for pharmaceutical research.

Chris Heger

Director of Applications Science, Analytical Solutions Division at Bio-Techne

Chris Heger is the Director of Applications Science for the Analytical Solutions Division of Bio-Techne. He received his Ph.D. in Pharmacology from Cornell University and completed his post-doctoral training at the National Cancer Institute. He then joined Bio-Techne, where he has worked for 13 years. He is an SME in capillary electrophoresis and immunoassays, is a member of Bio-Techne’s Science and Technology Council.

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