Ensuring success in AAV scale-up: key data from case studies across four serotypes

Tuesday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST

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Ensuring success in AAV scale-up: key data from case studies across four serotypes

Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format.

Explore key considerations and best practices for scaling AAV production, including selecting a transient transfection cell line and scale-up strategies for rAAV processes.

Data from small-scale case studies across four AAV serotypes will be explored, demonstrating:

scale-up of an rAAV9 process at 50 L and 200 L scale with yields of ≥ 2 × 10¹¹ vg/mL
low hcDNA (including encapsidated)
post-affinity chromatography yields of < 18 ng/10¹⁴ vg.

Leave with a roadmap for process scale-up in single-use bioreactor systems along with insights into choosing the best tools and cell lines for your application and serotype.

Attend this webinar to:

Gain knowledge of rAAV production process development
Learn how to best approach process scale-up
Understand why cell line selection is key to success

Kelly Cybulski

Senior Scientist, R&D at Cytiva

Kelly Cybulski is a Senior Scientist in R&D at Cytiva, where she has spent the past six years advancing viral vector process and product development. With a Master’s degree in Cell and Molecular Biology from the University of Rhode Island and 19 years of experience spanning GMP (Good Manufacturing Practice) production, process development, and research, Kelly brings deep technical expertise and a proven track record of innovation in biopharmaceutical manufacturing.

Kyle Burrell

Upstream Field Application Specialist at Cytiva

Kyle joined Cytiva in 2022 as a Bioreactor Application Specialist, bringing with him a strong background in bioreactor scale-up and process development. In 2023, he became part of the Genomic Medicine Operating Company, where he now focuses on viral vector technologies. Prior to joining Cytiva, Kyle worked in assay and analytical development for viral vectors. He holds a Master’s degree in Veterinary Medical Sciences from the University of Calgary, with a specialization in Comparative Biology, Experimental Medicine, and Stem Cell research.

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