Automating and scaling T cell manufacturing in hollow-fiber bioreactors

Wednesday 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET

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Automating and scaling T cell manufacturing in hollow-fiber bioreactors

This webinar presents data-driven approaches for activating, transducing, and expanding T cells in a fully automated hollow-fiber bioreactor. Attendees will see case studies showing how integrated workflows support CAR-T and TCR-T manufacturing across a range of starting materials, media formats, and viral vectors – demonstrating consistent expansion of 5 billion cells in 10 days.

The session will also outline strategies to scale from low starting densities to therapeutic doses, helping developers streamline process steps, strengthen efficiency, and address common constraints in early and late-stage programs.

Attend this webinar to:

Review robust data sets demonstrating reproducible T-cell activation, transduction, and expansion in a fully automated hollow-fiber bioreactor, including case studies from global research and technology centers
Compare workflow options using soluble or bead-based activators, serum-free or serum-containing media, PBMC or isolated T-cell starting material, and lentiviral or gamma-retroviral vectors
Learn practical strategies to scale from limited seed densities to therapeutic doses while conserving key attributes such as stem cell memory T-cell phenotype
Gain ready-to-use protocols and guidance for converting manual T-cell workflows into automated, scalable, and GMP-compatible closed-system processes

Register now to access real-world data, practical protocols, and workflow insights that support efficient, scalable, and automated T-cell manufacturing.

See More from Terumo Blood and Cell Technologies:

Mindy Miller, PhD

Head of Scientific Development - Global at Terumo Blood and Cell Technologies

Mindy Miller, PhD, currently serves as the Head of Cell Therapy Scientific Development at Terumo BCT leading global scientific efforts. She holds a doctorate in Immunology from University of Missouri and conducted post-doctoral studies at University of Missouri as well as National Jewish Health in Denver, CO. Mindy’s expertise has focused on the development of immune cells in the context of autoimmunity, allergy and asthma, pulmonary wound healing, and oncology. She has authored over 30 scientific publications, obtained independent funding, and was the recipient of the Young Investigator Award from the American Association of Immunologists.

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