Evaluating mRNA capping systems: experimental strategies for mRNA manufacturing

Tuesday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST

Sponsor

Evaluating mRNA capping systems: experimental strategies for mRNA manufacturing

As mRNA-based therapeutics continue to evolve, the need for robust, scalable, and high-yield manufacturing processes has never been greater. Robust and cost-effective mRNA capping is critical to ensuring high-quality, stable, and efficient RNA products, while making new vaccines and therapeutics more accessible to the broader market.

In this webinar, comparative performance data and practical insights will be shared to help you evaluate and optimize your capping processes. We will also explore characterization techniques, including cell-based potency assays and how mass spectrometry can be used to assess capping efficiency and inform process design for improved mRNA stability and translation.

Attend this webinar to:

Learn methodologies for optimizing the IVT and capping procedures to fit your target product, including methods of streamlining the capping reaction suitable to the type of molecule
See comparative performance data of various capping solutions, including a novel capping system, highlighting how these impact critical quality attributes, such as capping efficiency, mRNA yield and potency, both for non-self-amplifying and self-amplifying RNA
Understand available key technologies and learn strategies to thoroughly assess and characterize raw materials for mRNA manufacturing
Gain practical tips on optimizing an efficient mRNA capping reaction and determine the optimal ratio of capping enzymes to mRNA

Scott Alderucci

Director, Process Development at Curia Biologics

Scott Alderucci is the director of process development overseeing the Process Development and GMP divisions of mRNA at Curia. His department handles a variety of different programs for companies across the U.S and overseas. These include proof of concept through late-stage development and assisting in accelerating programs through the pipeline. His background encompasses both production, purification and analytical development for mammalian and RNA programs.

Julian Mochayedi

Product Manager EMEA/LATAM at Roche CustomBiotech

Dr. Julian Mochayedi serves as the mRNA Portfolio Product & Marketing Manager for Roche CustomBiotech EMEA/LATAM, Roche's business-to-business division providing high-quality, GMP-grade mRNA raw materials. His deep expertise in the mRNA field is further enhanced by his translational research background from the DKFZ German Cancer Research Center. Julian's academic credentials include an M.Sc. in Bioprocess Development and a Ph.D. in Translational Immunology, from Heidelberg University.

You have registered for this webinar