Producing low-immunogenicity, high-stability mRNA with dsRNA reduction to <0.005% (LLOQ)

Nucleic Acid Insights 2025; 2(4), 103

DOI: 10.18609/nuc.2025.016

Published: 21 May
FastFacts
Jen Dennin


Optimizing mRNA design for therapeutic applications is critical to ensure maximum protein expression, low impurities and a reduced immune response. This poster describes how to efficiently generate lower immunogenicity mRNA for downstream applications while also reducing dsRNA using the INCOGNITO™ mScript™ Complete mRNA Production Systems.

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